SEC61A2

General Information

Full gene name:Sec61 alpha 2 subunit (S. cerevisiae) Entrez Gene ID:55176 Location:10p14 Synonyms: Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs12779790	116053	downstream

NCBI Summary

The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

OMIM

No OMIM data available for this gene.

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• endoplasmic reticulum membrane
• molecular_function
• antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
• phagocytic vesicle membrane
• antigen processing and presentation of peptide antigen via MHC class I
• P-P-bond-hydrolysis-driven protein transmembrane transporter activity
• ribosome binding
• integral to membrane
• biological_process
• antigen processing and presentation of exogenous peptide antigen via MHC class I

KEGG Pathways

• Protein processing in endoplasmic reticulum
• Vibrio cholerae infection
• Phagosome
• Protein export

GeneRIFs

• Affinity Capture-MS [PMID 20562859]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 16385451]
• Affinity Capture-MS [PMID 21987572]
• Affinity Capture-MS [PMID 19615732]

PubMed Articles

Recent articles:

• Lee KA et al. “Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.” J Biol Chem. 2011 Dec 2;286(48):41530-8. PMID 21987572
• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
• Behrends C et al. “Network organization of the human autophagy system.” Nature. 2010 Jul 1;466(7302):68-76. PMID 20562859
• Sowa ME et al. “Defining the human deubiquitinating enzyme interaction landscape.” Cell. 2009 Jul 23;138(2):389-403. PMID 19615732
• Grupe A et al. “A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.” Am J Hum Genet. 2006 Jan;78(1):78-88. PMID 16385451
• Suzuki Y et al. “Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.” Genome Res. 2004 Sep;14(9):1711-8. PMID 15342556
• Ota T et al. “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Nat Genet. 2004 Jan;36(1):40-5. PMID 14702039
• Strausberg RL et al. “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.” Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. PMID 12477932
• Kawai J et al. “Functional annotation of a full-length mouse cDNA collection.” Nature. 2001 Feb 8;409(6821):685-90. PMID 11217851

Top Pubmed articles linked to gene SEC61A2 matching any search term:

• Dodson G et al. “The role of assembly in insulin’s biosynthesis.” Curr Opin Struct Biol. 1998 Apr;8(2):189-94. PMID 9631292