SLC36A4

General Information

Full gene name:solute carrier family 36 (proton/amino acid symporter), member 4 Entrez Gene ID:120103 Location:11q21 Synonyms:PAT4 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs10830963	172140	downstream

NCBI Summary

SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family members (e.g., SLC36A1; MIM 606561). SLC36 proteins contain about 500 amino acids and have 9 to 11 transmembrane domains. Unlike other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is a high-affinity/low-capacity non-proton-coupled amino acid transporter (Pillai and Meredith, 2011 [PubMed 21097500]).[supplied by OMIM, Feb 2011]

OMIM

OMIM ID:`OMIM ID 613760 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• proline transport
• tryptophan transport
• integral to membrane
• symporter activity
• L-alanine transport

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• SLC36A4 has a similar in vivo growth regulatory activity to fly SLC36 family members when expressed in Drosophila and is also required for amino acid-dependent mTORC1 activation, and mTORC1-regulated proliferation in human cells. [PMID 20498635]
• SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes. [PMID 21097500]

PubMed Articles

Recent articles:

• Pillai SM et al. “SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes.” J Biol Chem. 2011 Jan 28;286(4):2455-60. PMID 21097500
• Heublein S et al. “Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation.” Oncogene. 2010 Jul 15;29(28):4068-79. PMID 20498635
• Ota T et al. “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Nat Genet. 2004 Jan;36(1):40-5. PMID 14702039
• Strausberg RL et al. “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.” Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. PMID 12477932