SV2B

General Information

Full gene name:synaptic vesicle glycoprotein 2B Entrez Gene ID:9899 Location:15q26.1 Synonyms:HsT19680 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs8042680	121845	upstream

NCBI Summary

None available.

OMIM

OMIM ID:`OMIM ID 185861 `_

NCBI Phenotypes

• Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.
• NHGRI GWA Catalog

Gene Ontology

• synaptic vesicle membrane
• acrosomal vesicle
• transmembrane transporter activity
• integral to membrane
• neurotransmitter transport
• cell junction

KEGG Pathways

• ECM-receptor interaction

GeneRIFs

• Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [PMID 20628086]
• Affinity Capture-Western [PMID 15466855]
• Affinity Capture-Western [PMID 15466855]
• Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 20379614]
• Synaptic vesicle protein 2 binds adenine nucleotides [PMID 18524768]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 19913121]

PubMed Articles

Recent articles:

• Bailey SD et al. “Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.” Diabetes Care. 2010 Oct;33(10):2250-3. PMID 20628086
• Rose JE et al. “Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.” Mol Med. 2010 Jul-Aug;16(7-8):247-53. PMID 20379614
• Talmud PJ et al. “Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.” Am J Hum Genet. 2009 Nov;85(5):628-42. PMID 19913121
• Lynch JM et al. “No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy.” Epilepsy Res. 2009 Jan;83(1):44-51. PMID 18977120
• Gieger C et al. “Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.” PLoS Genet. 2008 Nov;4(11):e1000282. PMID 19043545
• Yao J et al. “Synaptic vesicle protein 2 binds adenine nucleotides.” J Biol Chem. 2008 Jul 25;283(30):20628-34. PMID 18524768
• Verma R et al. “Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3.” Biol Psychiatry. 2008 Jun 15;63(12):1185-9. PMID 18367154
• Girard A et al. “A germline-specific class of small RNAs binds mammalian Piwi proteins.” Nature. 2006 Jul 13;442(7099):199-202. PMID 16751776
• Lazzell DR et al. “SV2B regulates synaptotagmin 1 by direct interaction.” J Biol Chem. 2004 Dec 10;279(50):52124-31. PMID 15466855
• Gerhard DS et al. “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” Genome Res. 2004 Oct;14(10B):2121-7. PMID 15489334

Top Pubmed articles linked to gene SV2B matching any search term:

• Bailey SD et al. “Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.” Diabetes Care. 2010 Oct;33(10):2250-3. PMID 20628086
• Iezzi M et al. “SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment.” J Cell Sci. 2005 Dec 1;118(Pt 23):5647-60. PMID 16306227
• Bajjalieh SM et al. “Brain contains two forms of synaptic vesicle protein 2.” Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2150-4. PMID 7681585