SYNRG

General Information

Full gene name:synergin, gamma Entrez Gene ID:11276 Location:17q12 Synonyms:SYNG, AP1GBP1 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs757210	127029	upstream

NCBI Summary

This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

OMIM

No OMIM data available for this gene.

NCBI Phenotypes

• NHGRI GWA Catalog
• Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.

Gene Ontology

• calcium ion binding
• Golgi apparatus
• cytoplasm
• endocytosis
• AP-1 adaptor complex
• intracellular protein transport

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Two-hybrid [PMID 10814529]
• Two-hybrid [PMID 10814529]
• AP-3 and AP-1 function in partially redundant pathways to transfer tyrosinase from distinct endosomal subdomains to melanosomes [PMID 16162817]
• Reconstituted Complex; Two-hybrid [PMID 10777571]
• Data show that by recruiting aftiphilin/gamma-synergin in addition to clathrin, AP-1 coordinates formation of Weibel-Palade bodies with their acquisition of a regulated secretory phenotype. [PMID 18815278]
• the aftiphilin/p200/gamma-synergin complex facilitates AP-1 function [PMID 15758025]
• Reconstituted Complex; Two-hybrid [PMID 12042876]

PubMed Articles

Recent articles:

• Turner ST et al. “Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.” Hypertension. 2012 Jun;59(6):1204-11. PMID 22566498
• Lui-Roberts WW et al. “Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells.” Mol Biol Cell. 2008 Dec;19(12):5072-81. PMID 18815278
• Kimura K et al. “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.” Genome Res. 2006 Jan;16(1):55-65. PMID 16344560
• Theos AC et al. “Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes.” Mol Biol Cell. 2005 Nov;16(11):5356-72. PMID 16162817
• Hirst J et al. “The aftiphilin/p200/gamma-synergin complex.” Mol Biol Cell. 2005 May;16(5):2554-65. PMID 15758025
• Gerhard DS et al. “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” Genome Res. 2004 Oct;14(10B):2121-7. PMID 15489334
• Beausoleil SA et al. “Large-scale characterization of HeLa cell nuclear phosphoproteins.” Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5. PMID 15302935
• Ota T et al. “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Nat Genet. 2004 Jan;36(1):40-5. PMID 14702039
• Lui WW et al. “Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin.” Mol Biol Cell. 2003 Jun;14(6):2385-98. PMID 12808037
• Mills IG et al. “EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking.” J Cell Biol. 2003 Jan 20;160(2):213-22. PMID 12538641

Top Pubmed articles linked to gene SYNRG matching any search term:

• Hendrix NW et al. “Prenatally diagnosed 17q12 microdeletion syndrome with a novel association with congenital diaphragmatic hernia.” Fetal Diagn Ther. 2012;31(2):129-33. PMID 22178801