THADA

General Information

Full gene name:thyroid adenoma associated Entrez Gene ID:63892 Location:2p21 Synonyms:GITA Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs7578597	0	within

NCBI Summary

None available.

OMIM

OMIM ID:`OMIM ID 611800 `_

NCBI Phenotypes

• New gene functions in megakaryopoiesis and platelet formation.
• Common variants in the trichohyalin gene are associated with straight hair in Europeans.
• Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
• Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
• Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.
• Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci.
• Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
• NHGRI GWA Catalog
• Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.

Gene Ontology

No GO terms found linked to this gene.

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [PMID 20889853]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 20816152]
• Meta-analysis of gene-disease association. (HuGE Navigator) [PMID 20564319]
• Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) [PMID 20075150]
• intronic sequence of PPAR(gamma) is fused to exon 28 of THADA in thyroid tumors of follicular origin including carcinomas as well as adenomas [PMID 17123335]
• Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) [PMID 18372903]
• Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 20379614]
• Affinity Capture-MS [PMID 21987572]
• Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) [PMID 20571754]
• Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 20878950]
• Meta-analysis and HuGE review of gene-disease association. (HuGE Navigator) [PMID 19602701]
• Observational study and meta-analysis of gene-disease association. (HuGE Navigator) [PMID 20490451]
• Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [PMID 20879858]
• identification of the target gene of 2p21 aberrations in thyroid adenomas tentatively referred to as thyroid adenoma-associated gene (THADA); gene spans roughly 365 kbp; based on preliminary results, it encodes a death receptor-interacting protein [THADA] [PMID 12955091]
• At least two of the PCOS susceptibility loci identified in the Chinese PCOS GWAS (DENND1A and THADA) are also associated with PCOS in European derived populations. [PMID 22180642]

PubMed Articles

Recent articles:

• Goodarzi MO et al. “Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts.” J Med Genet. 2012 Feb;49(2):90-5. PMID 22180642
• Lee KA et al. “Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.” J Biol Chem. 2011 Dec 2;286(48):41530-8. PMID 21987572
• Patsopoulos NA et al. “Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.” Ann Neurol. 2011 Dec;70(6):897-912. PMID 22190364
• Gieger C et al. “New gene functions in megakaryopoiesis and platelet formation.” Nature. 2011 Nov 30;480(7376):201-8. PMID 22139419
• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
• Danielsen JM et al. “Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.” Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. PMID 21139048
• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Chen ZJ et al. “Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.” Nat Genet. 2011 Jan;43(1):55-9. PMID 21151128
• Franke A et al. “Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci.” Nat Genet. 2010 Dec;42(12):1118-25. PMID 21102463

Top Pubmed articles linked to gene THADA matching any search term:

• Eriksen MB et al. “Association of polycystic ovary syndrome susceptibility single nucleotide polymorphism rs2479106 and PCOS in Caucasian patients with PCOS or hirsutism as referral diagnosis.” Eur J Obstet Gynecol Reprod Biol. 2012 Jul;163(1):39-42. PMID 22504079
• Hotta K et al. “Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.” J Hum Genet. 2012 May;57(5):305-10. PMID 22377712
• Saxena R et al. “Polycystic ovary syndrome is not associated with genetic variants that mark risk of type 2 diabetes.” Acta Diabetol. 2012 Mar 3;. PMID 22389004
• Gupta V et al. “Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs.” Diabetologia. 2012 Feb;55(2):349-57. PMID 22052079
• Goodarzi MO et al. “Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts.” J Med Genet. 2012 Feb;49(2):90-5. PMID 22180642
• Cheng I et al. “Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies.” Gut. 2011 Dec;60(12):1703-11. PMID 21602532
• Vangipurapu J et al. “Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men.” Diabetologia. 2011 Mar;54(3):563-71. PMID 21153532
• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Klimentidis YC et al. “Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of children.” Hum Genomics. 2011 Jan;5(2):79-89. PMID 21296741
• Stuebe AM et al. “Obesity and diabetes genetic variants associated with gestational weight gain.” Am J Obstet Gynecol. 2010 Sep;203(3):283.e1-17. PMID 20816152
• Morgan AR et al. “Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.” BMC Med Genet. 2010 Aug 16;11:125. PMID 20712903
• Pierce BL et al. “Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.” Hum Hered. 2010;69(3):193-201. PMID 20203524
• Talmud PJ et al. “Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.” BMJ. 2010 Jan 14;340:b4838. PMID 20075150
• Schleinitz D et al. “Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits.” Horm Metab Res. 2010 Jan;42(1):14-22. PMID 19670153
• Parikh H et al. “Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.” BMC Med Genomics. 2009 Dec 31;2:72. PMID 20043853
• Schulze MB et al. “Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study.” Diabetes Care. 2009 Nov;32(11):2116-9. PMID 19720844
• Hu C et al. “PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.” PLoS One. 2009 Oct 28;4(10):e7643. PMID 19862325
• Stancáková A et al. “Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.” Diabetes. 2009 Sep;58(9):2129-36. PMID 19502414
• Lin X et al. “Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score–the CoLaus Study.” Diabetologia. 2009 Apr;52(4):600-8. PMID 19139842