TLE4

General Information

Full gene name:transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) Entrez Gene ID:7091 Location:9q21.31 Synonyms:E(spI), GRG4, ESG4, BCE1, BCE-1, ESG Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs13292136	234750	upstream

NCBI Summary

None available.

OMIM

OMIM ID:`OMIM ID 605132 `_

NCBI Phenotypes

• NHGRI GWA Catalog
• Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.
• Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.

Gene Ontology

• negative regulation of transcription from RNA polymerase II promoter
• chromatin binding
• Wnt receptor signaling pathway
• nucleoplasm
• repressing transcription factor binding
• molecular_function
• nucleus
• transcription, DNA-dependent
• transcription corepressor activity
• biological_process
• Notch signaling pathway

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• germ cell-specific RBMY and hnRNP G-T proteins were more efficient in stimulating TLE4-T incorporation than somatically expressed hnRNP G protein. [PMID 19893608]
• Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [PMID 20889853]
• Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [PMID 19714205]
• Knockdown of TLE1 or TLE4 levels increased the rate of cell division of the AML1-ETO-expressing Kasumi-1 cell line, whereas forced expression of either TLE1 or TLE4 caused apoptosis and cell death. [PMID 18258796]
• Affinity Capture-MS [PMID 21890473]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 20816195]
• Grg4 recruits the arginine methyltransferase PRMT5 to chromatin resulting in symmetric H4R3 dimethylation. [PMID 22169276]
• Affinity Capture-MS; Affinity Capture-Western [PMID 22169276]
• Affinity Capture-MS; Affinity Capture-Western [PMID 22169276]
• Affinity Capture-MS; Affinity Capture-Western [PMID 22169276]
• Affinity Capture-Western [PMID 11266540]
• Affinity Capture-Western; Reconstituted Complex [PMID 19332113]
• Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors [PMID 17060451]
• Affinity Capture-Western; Reconstituted Complex; Two-hybrid [PMID 12153506]

PubMed Articles

Recent articles:

• Patel SR et al. “Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression.” Mol Cell. 2012 Jan 27;45(2):185-95. PMID 22169276
• Al-Balool HH et al. “Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant.” Genome Res. 2011 Nov;21(11):1788-99. PMID 21948523
• Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
• Danielsen JM et al. “Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.” Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. PMID 21139048
• Jiang Y et al. “Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.” Genet Epidemiol. 2011 Feb;35(2):125-32. PMID 21254220
• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Melén E et al. “Analyses of shared genetic factors between asthma and obesity in children.” J Allergy Clin Immunol. 2010 Sep;126(3):631-7.e1-8. PMID 20816195
• Liu Y et al. “The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon.” PLoS Genet. 2009 Nov;5(11):e1000707. PMID 19893608
• Hancock DB et al. “Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.” PLoS Genet. 2009 Aug;5(8):e1000623. PMID 19714205
• Sharma M et al. “The homeodomain protein Cux1 interacts with Grg4 to repress p27 kip1 expression during kidney development.” Gene. 2009 Jun 15;439(1-2):87-94. PMID 19332113

Top Pubmed articles linked to gene TLE4 matching any search term:

• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Hoffman BG et al. “Expression of Groucho/TLE proteins during pancreas development.” BMC Dev Biol. 2008 Sep 8;8:81. PMID 18778483
• Doyle MJ et al. “Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.” Development. 2007 Feb;134(3):515-23. PMID 17202186