TREX2

General Information

Full gene name:three prime repair exonuclease 2 Entrez Gene ID:11219 Location:Xq28 Synonyms: Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs3020789	181042	upstream

NCBI Summary

This gene encodes a protein with 3’ exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity. [provided by RefSeq, Jul 2008]

OMIM

OMIM ID:`OMIM ID 300370 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• exodeoxyribonuclease III activity
• nucleic acid binding
• DNA repair
• nucleus
• 3’-5’-exodeoxyribonuclease activity

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Trex2 does not enable DSB repair and prompt a new model that posits Trex2 suppresses the formation of broken chromosomes. [PMID 21546543]
• Two-hybrid [PMID 16189514]
• analysis of human TREX2 3’ -> 5’-exonuclease structure and description of the mechanism for efficient nonprocessive DNA catalysis [PMID 15661738]
• Co-fractionation [PMID 11279105]
• analysis of cooperative DNA binding and communication across the dimer interface in the TREX2 3’ –> 5’-exonuclease [PMID 18534978]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 18092167]
• a model for DNA binding and 3’ hydrolysis for the TREX2 dimer. [PMID 19321497]
• Polymorphisms exist in prostatic cancer patients. [PMID 15581481]
• Trex2 deletion caused high levels of Robertsonian translocations (RbTs) showing Trex2 is important for chromosomal maintenance. [PMID 19094998]
• Results suggest that TREX2 plays an important function during DNA metabolism and cellular proliferation. [PMID 17426129]
• UCH37 interacts with UIP1. [PMID 11163772]

PubMed Articles

Recent articles:

• Dumitrache LC et al. “Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair.” Genetics. 2011 Aug;188(4):787-97. PMID 21546543
• de Silva U et al. “DNA binding induces active site conformational change in the human TREX2 3’-exonuclease.” Nucleic Acids Res. 2009 Apr;37(7):2411-7. PMID 19321497
• Dumitrache LC et al. “TREX2 exonuclease defective cells exhibit double-strand breaks and chromosomal fragments but not Robertsonian translocations.” Mutat Res. 2009 Mar 9;662(1-2):84-7. PMID 19094998
• Perrino FW et al. “Cooperative DNA binding and communication across the dimer interface in the TREX2 3’ –> 5’-exonuclease.” J Biol Chem. 2008 Aug 1;283(31):21441-52. PMID 18534978
• Hur JW et al. “TREX1 polymorphisms associated with autoantibodies in patients with systemic lupus erythematosus.” Rheumatol Int. 2008 Jun;28(8):783-9. PMID 18092167
• Chen MJ et al. “Biochemical and cellular characteristics of the 3’ -> 5’ exonuclease TREX2.” Nucleic Acids Res. 2007;35(8):2682-94. PMID 17426129
• Hahn Y et al. “Human-specific nonsense mutations identified by genome sequence comparisons.” Hum Genet. 2006 Mar;119(1-2):169-78. PMID 16395595
• Mehrle A et al. “The LIFEdb database in 2006.” Nucleic Acids Res. 2006 Jan 1;34(Database issue):D415-8. PMID 16381901
• Rual JF et al. “Towards a proteome-scale map of the human protein-protein interaction network.” Nature. 2005 Oct 20;437(7062):1173-8. PMID 16189514
• Perrino FW et al. “The human TREX2 3’ -> 5’-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis.” J Biol Chem. 2005 Apr 15;280(15):15212-8. PMID 15661738

Top Pubmed articles linked to gene TREX2 matching any search term:

• Chu Q et al. “Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin.” Clin Experiment Ophthalmol. 2011 Mar;39(2):142-51. PMID 20973890
• Colbert LH et al. “Exercise effects on tumorigenesis in a p53-deficient mouse model of breast cancer.” Med Sci Sports Exerc. 2009 Aug;41(8):1597-605. PMID 19568200