UNC45A

General Information

Full gene name:unc-45 homolog A (C. elegans) Entrez Gene ID:55898 Location:15q26.1 Synonyms:SMAP1, GCUNC-45, GCUNC45, GC-UNC45, IRO039700, SMAP-1 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs8042680	24014	downstream

NCBI Summary

UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]).[supplied by OMIM, Mar 2008]

OMIM

OMIM ID:`OMIM ID 611219 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• chaperone-mediated protein folding
• muscle organ development
• Hsp90 protein binding
• nucleus
• perinuclear region of cytoplasm
• cell differentiation

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• GCUNC45 is required for the normal cellular distribution of Hsp90beta, but not Hsp90alpha. [PMID 18285346]
• elevated GC UNC-45 protein expression in ovarian carcinoma proliferation and metastasis. [PMID 17872978]
• Affinity Capture-MS [PMID 19615732]
• Affinity Capture-MS [PMID 20562859]
• Affinity Capture-MS [PMID 21906983]
• The authors found that UNC-45A is alternatively expressed at the mRNA and protein levels as two isoforms and that the two isoforms differ only by a proline-rich 15-amino-acid sequence near the amino-terminus. [PMID 21802425]
• GCUNC-45 is a novel modulator of progesterone receptor chaperoning by hsp90. [PMID 16478993]

PubMed Articles

Recent articles:

• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
• Guo W et al. “Differential turnover of myosin chaperone UNC-45A isoforms increases in metastatic human breast cancer.” J Mol Biol. 2011 Sep 23;412(3):365-78. PMID 21802425
• Danielsen JM et al. “Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.” Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. PMID 21139048
• Behrends C et al. “Network organization of the human autophagy system.” Nature. 2010 Jul 1;466(7302):68-76. PMID 20562859
• Sowa ME et al. “Defining the human deubiquitinating enzyme interaction landscape.” Cell. 2009 Jul 23;138(2):389-403. PMID 19615732
• Chadli A et al. “GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificity.” J Biol Chem. 2008 Apr 11;283(15):9509-12. PMID 18285346
• Bazzaro M et al. “Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility.” Am J Pathol. 2007 Nov;171(5):1640-9. PMID 17872978
• Ewing RM et al. “Large-scale mapping of human protein-protein interactions by mass spectrometry.” Mol Syst Biol. 2007;3:89. PMID 17353931
• Olsen JV et al. “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Cell. 2006 Nov 3;127(3):635-48. PMID 17081983