VTI1A

General Information

Full gene name:vesicle transport through interaction with t-SNAREs homolog 1A (yeast) Entrez Gene ID:143187 Location:10q25.2 Synonyms:MVti1, Vti1-rp2, VTI1RP2 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs7903146	179845	downstream

NCBI Summary

None available.

OMIM

OMIM ID:`OMIM ID 614316 `_

NCBI Phenotypes

• Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.
• NHGRI GWA Catalog

Gene Ontology

• ER to Golgi vesicle-mediated transport
• SNARE complex
• vesicle fusion with Golgi apparatus
• Golgi apparatus
• SNAP receptor activity
• Golgi membrane
• neuronal cell body
• retrograde transport, endosome to Golgi
• integral to membrane
• intracellular protein transport
• synaptic vesicle

KEGG Pathways

• SNARE interactions in vesicular transport

GeneRIFs

• The present results suggest that a SNARE complex containing VAMP7 and Vti1a defines a novel traffic pathway to the cell surface in both neuronal and non-neuronal cells. [PMID 19138172]
• Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 20379614]
• Affinity Capture-Western [PMID 11101518]
• Affinity Capture-Western; Co-purification [PMID 11101518]
• Affinity Capture-Western [PMID 11101518]
• Affinity Capture-Western [PMID 11839770]
• Affinity Capture-Western [PMID 11839770]
• Affinity Capture-MS; Reconstituted Complex [PMID 21906983]
• We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. [PMID 21892161]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 19023099]

PubMed Articles

Recent articles:

• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Bass AJ et al. “Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.” Nat Genet. 2011 Sep 4;43(10):964-8. PMID 21892161
• Danielsen JM et al. “Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.” Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. PMID 21139048
• Sotoodehnia N et al. “Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.” Nat Genet. 2010 Dec;42(12):1068-76. PMID 21076409
• Rose JE et al. “Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.” Mol Med. 2010 Jul-Aug;16(7-8):247-53. PMID 20379614
• Nishimoto-Morita K et al. “Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes.” J Biol Chem. 2009 Apr 17;284(16):10583-92. PMID 19224922
• Flowerdew SE et al. “A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels.” Biochem J. 2009 Mar 15;418(3):529-40. PMID 19138172
• Luke MM et al. “Gene variants associated with ischemic stroke: the cardiovascular health study.” Stroke. 2009 Feb;40(2):363-8. PMID 19023099
• Shiffman D et al. “Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.” Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):173-9. PMID 17975119
• Grupe A et al. “A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.” Am J Hum Genet. 2006 Jan;78(1):78-88. PMID 16385451

Top Pubmed articles linked to gene VTI1A matching any search term:

• Behre CJ et al. “Dissociation between adipose tissue expression and serum levels of adiponectin during and after diet-induced weight loss in obese subjects with and without the metabolic syndrome.” Metabolism. 2007 Aug;56(8):1022-8. PMID 17618945
• Bose A et al. “The v-SNARE Vti1a regulates insulin-stimulated glucose transport and Acrp30 secretion in 3T3-L1 adipocytes.” J Biol Chem. 2005 Nov 4;280(44):36946-51. PMID 16131485