ZBED3

General Information

Full gene name:zinc finger, BED-type containing 3
Entrez Gene ID:84327
Location:5q13.3
Synonyms:
Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP Distance (bp) Direction
rs4457053 41919 upstream

NCBI Summary

None available.

OMIM

No OMIM data available for this gene.

NCBI Phenotypes

  • Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
  • NHGRI GWA Catalog

Gene Ontology

  • DNA binding
  • metal ion binding

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

  • Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [PMID 20889853]
  • Zbed3 is a novel Axin-binding protein that is involved in Wnt/beta-catenin signaling modulation. [PMID 19141611]

PubMed Articles

Recent articles:

  • de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
  • Voight BF et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.” Nat Genet. 2010 Jul;42(7):579-89. PMID 20581827
  • Chen T et al. “Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling.” J Biol Chem. 2009 Mar 13;284(11):6683-9. PMID 19141611
  • Gerhard DS et al. “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” Genome Res. 2004 Oct;14(10B):2121-7. PMID 15489334
  • Strausberg RL et al. “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.” Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. PMID 12477932
  • Maruyama K et al. “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.” Gene. 1994 Jan 28;138(1-2):171-4. PMID 8125298

Top Pubmed articles linked to gene ZBED3 matching any search term:

  • Ohshige T et al. “Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese.” PLoS One. 2011;6(10):e26911. PMID 22046406
  • Nielsen T et al. “Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release.” Diabetologia. 2011 May;54(5):1052-6. PMID 21267535
  • de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
  • Voight BF et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.” Nat Genet. 2010 Jul;42(7):579-89. PMID 20581827

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