ZFAND6

General Information

Full gene name:zinc finger, AN1-type domain 6 Entrez Gene ID:54469 Location:15q25.1 Synonyms:AWP1, ZA20D3, ZFAND5B Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs11634397	1512	downstream

NCBI Summary

None available.

OMIM

OMIM ID:`OMIM ID 610183 `_

NCBI Phenotypes

• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
• NHGRI GWA Catalog

Gene Ontology

• regulation of I-kappaB kinase/NF-kappaB cascade
• polyubiquitin binding
• molecular_function
• cytoplasm
• DNA binding
• cellular_component
• apoptotic process
• zinc ion binding
• regulation of apoptotic process
• cellular response to tumor necrosis factor
• protein targeting to peroxisome
• biological_process

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Affinity Capture-MS [PMID 21890473]
• Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [PMID 20889853]
• The AN1 domain of AWP1 mediated the functional interaction with tumor necrosis factor receptor-associated factor 2, and the A20 domain was responsible for the negative regulation of nuclear factor kappaB activation. [PMID 21810480]
• Affinity Capture-Western; Reconstituted Complex; Two-hybrid [PMID 21810480]
• Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [PMID 20549515]
• Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 20379614]

PubMed Articles

Recent articles:

• Chang EJ et al. “AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling.” Int J Biochem Cell Biol. 2011 Nov;43(11):1612-20. PMID 21810480
• Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Feng T et al. “Genome-wide searching of rare genetic variants in WTCCC data.” Hum Genet. 2010 Sep;128(3):269-80. PMID 20549515
• Voight BF et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.” Nat Genet. 2010 Jul;42(7):579-89. PMID 20581827
• Rose JE et al. “Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.” Mol Med. 2010 Jul-Aug;16(7-8):247-53. PMID 20379614
• Kimura K et al. “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.” Genome Res. 2006 Jan;16(1):55-65. PMID 16344560
• Rual JF et al. “Towards a proteome-scale map of the human protein-protein interaction network.” Nature. 2005 Oct 20;437(7062):1173-8. PMID 16189514
• Stelzl U et al. “A human protein-protein interaction network: a resource for annotating the proteome.” Cell. 2005 Sep 23;122(6):957-68. PMID 16169070
• Cao YK et al. “[Construction of GFP-AWP1 fusion gene vector and its expression in 293 cells].” Di Yi Jun Yi Da Xue Xue Bao. 2005 Feb;25(2):174-6, 180. PMID 15698998

Top Pubmed articles linked to gene ZFAND6 matching any search term:

• Ohshige T et al. “Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese.” PLoS One. 2011;6(10):e26911. PMID 22046406
• Nielsen T et al. “Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release.” Diabetologia. 2011 May;54(5):1052-6. PMID 21267535
• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Feng T et al. “Genome-wide searching of rare genetic variants in WTCCC data.” Hum Genet. 2010 Sep;128(3):269-80. PMID 20549515
• Voight BF et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.” Nat Genet. 2010 Jul;42(7):579-89. PMID 20581827