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Significant Publications

  1. Zhou W, Nielsen JB, Fritsche LG, Dey R, Gabrielsen ME, Wolford BN, LeFaive J, VandeHaar P, Gagliano SA, Gifford A, Bastarache LA, Wei WQ, Denny JC, Lin M, Hveem K, Kang HM, Abecasis GR, Willer CJ, Lee S (2018). Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies. Nat Genet
  2. Nielsen JB, Thorolfsdottir RB, Fritsche LG, Zhou W, Skov MW, Graham SE, Herron TJ, McCarthy S, Schmidt EM, Sveinbjornsson G, … [many additional authors], Abecasis GR, Hveem K, Willer CJ (2018). Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. Nat Genet
  3. Wolford BN, Willer CJ, Surakka I (2018). Electronic health records: the next wave of complex disease genetics. Hum Mol Genet 27(R1):R14-R21.
  4. Nielsen JB, Fritsche LG, Zhou W, … [many additional authors], Kang HM, Abecasis GR, Hveem K, Willer CJ (2018). Genome-wide study of atrial fibrillation identifies seven risk loci and highlights biological pathways and regulatory elements involved in cardiac development. Am J Hum Genet 102(1):103-115.
  5. Liu DJ, Peloso GM, … [many additional authors], Abecasis G, Deloukas P, Musunuru K, Willer CJ, Kathiresan S (2017). Exome-wide association study of plasma lipids in >300,000 individuals. Nat Genet 49(12):1758-1766.
  6. Lu X, Peloso GM, Liu DJ, Wu Y, Zhang H, Zhou W, … [many additional authors], GLGC Consortium, Kathiresan S, Mohlke KL, Wu T, Sham PC, Gu D, Willer CJ (2017). Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease. Nat Genet 49(12):1722-1730.
  7. Yang B, Zhou W, Jiao J, … [many additional authors], Eriksson P, Tardif JC, Brummett CM, Milewicz DM, Body SC, Willer CJ (2017). Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve. Nat Commun 8:15481.
  8. Schmidt EM, Willer CJ (2015). Insights into blood lipids from rare variant discovery. Curr Opin Genet Dev 33:25-31.
  9. Lange LA, Willer CJ, Rich SS. (2015) Recent developments in genome- and exome-wide analyses of plasma lipids. (Invited Review) Current Opin Lipidol 26(2):96-102.
  10. Schmidt EM, Zhang J, Zhou W, Chen J, Mohlke KL, Chen E, Willer CJ (2015). GREGOR: Evaluating global enrichment of trait-associated variants in epigenomic features using a systematic, data-driven approach. Bioinformatics31(16):2601-6.
  11. Holmen OL*, Zhang H*, Zhou W*, Schmidt EM, Hovelson DH, Langhammer A, Lochen M-L, Ganesh SK, Mathiesen EB, Vatten L, Platou C, Wilsgaard T, Chen J, Skorpen F, Dalen H, Boehnke M, Abecasis GR, Njølstad I, Hveem K, Willer CJ. (2014) No large-effect low frequency coding variation found for myocardial infarction. Human Molecular Genetics 23:4721-8.
  12. Lange L*, Hu Y*, Zhang H*, Xue C, Tang Z, Bizon C, … [many additional authors], Cupples LA, Kooperberg C, Wilson JG, Nickerson DA, Abecasis GR, Rich SS, Tracy RP, Willer CJ, NHLBI Exome Sequencing Project. (2014) Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. American Journal of Human Genetics 94:233-45.
  13. Holmen OL*, Zhang H*, Schmidt EM, Fan Y, Hovelson D, Schmidt EM, Zhou W, Gou Y, Zhang J, Langhammer A, Lochen M-L, Ganesh SK, Vatten L, Skorpen F, Dalen H, Zhang J, Pennathur S, Chen J, Platou C, Mathiesen EB, Wilsgaard T, Njølstad I, Boehnke M, Chen YE, Abecasis GR, Hveem K, Willer CJ. (2014) Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol. Nature Genetics 46:345-351.
  14. Willer CJ*, Schmidt EM*, Sengupta S*, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich, ……. [many additional authors]. (2013) Discovery and refinement of loci associated with lipid levels. Nat Genet 45:1274-83.PMCID: PMC3838666
  15. The CARDIoGRAMplusC4D Consortium, Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, König IR, Cazier JB, Johansson A, Hall AS, Lee JY, Willer CJ, Chambers JC, Esko T, et al. (2013). Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 45(1):25-33. PMCID: PMC3679547
  16. Willer CJ, Li Y, Abecasis GR. (2010) METAL: Fast and efficient meta-analysis of genomewide association scans. Bioinformatics 2010 Sep 1;26(17):2190-1. PMCID: PMC2922887
  17. Pruim RJ*, Welch RP*, Sanna S, Teslovich TM, Chines PS, Gliedt TP, Boehnke M, Abecasis GR, Willer CJ. (2010) LocusZoom: Regional visualization of genome-wide association scan results. Bioinformatics 2010 Sep 15;26(18):2336-7. PMCID: PMC2935401
  18. Willer CJ*, Sanna S*, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, Heath SC, Timpson NJ, Najjar SS, Stringham HM, Strait J, Duren WL, Maschio A, Busonero F, Mulas A, Albai G, Swift AJ, Morken MA, Narisu N, Bennett D, Parish S, Shen H, Galan P, Meneton P, Hercberg S, Zelenika D, Chen W-M, Li Y, Scott LJ, Scheet PA, Sundvall J, Watanabe RM, Nagaraja R, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Davey-Smith G, Shuldiner AR, Collins R, Bergman RN, Uda M, Tuomilehto J, Cao A, Collins FS, Lakatta E, Lathrop GM, Boehnke M, Schlessinger D, Mohlke KL, Abecasis GR. (2008) Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 40(2):161-9
  19. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines P, Jackson AU, Prokunina-Olsson L, Ding C-J, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li X-Y, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M. (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316(5829):1341-5