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Sequential Csp3-H Arylation and Olefination: Total Synthesis of the Proposed Structure of Pipercyclobutanamide A

Gutekunst, W. R.; Gianatassio, R.; Baran, P. S. Angew. Chem. Int. Ed. 2012, 51, 7507-7510.

 

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Pipercyclobutanamide A is a naturally-occurring compound found
in the black pepper plant Piper nigrum. We present an intermediate step
of the synthesis of Pipercyclobutanamide A, which transforms Molecule 18 to Molecule 19.

 

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