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Puig, S., Lee, J., Lau, M. and Thiele, D.J. 2002. Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake. Journal of Biological Chemistry. (in press)
Hahn, J-S. and Thiele, D.J. 2002. Regulation of the Saccharomyces cerevisiae Slt2 Kinase Pathway by the Stress-inducible Sdp1 Dual Specificity Phosphatase. Journal of Biological Chemistry. (in press)
Puig, S. and Thiele, D. J. 2002. Molecular mechanisms of copper uptake and distribution. Current Opinion in Chemical Biology 6: 171-180. (PDF)
Lee, J., Peña, M.M.O., Nose, Y. and Thiele, D. J. 2002. Biochemical Characterization of the Human Copper Transporter Ctr1. Journal of Biological Chemistry 277, 4380-4387. (PDF)
Liu, P.C.C. and Thiele, D.J. 2001. Novel stress responsive genes EMG1 and NOP14 encode conserved interacting proteins required for 40S ribosome biogenesis. Molecular Biology of the Cell 12: 3644-3657. (PDF)
Ahn, S-G., Liu, P.C.C., Klyachko, K., Morimoto, R., and Thiele, D.J. 2001. The Loop Domain of Heat Shock Transcription Factor 1 Dictates DNA Bindng Specificity and Responses to Heat Stress. Genes and Development 15, 2134-2145. (PDF)
Koch, K.A., Allard, S., Santoro, N., Cote, J., and Thiele, D.J. 2001. The Candida glabrata Amt1 copper-sensing transcription factor requires Swi/Snf and Gcn5 at a critical step in copper detoxification. Molecular Microbiology 40(5), 1165-1174. (PDF)
Lee, J. Prohaska, J.R., and Thiele, D.J. 2001. Essential Role for Mammalian Copper Transporter Ctr1 in Copper Homeostasis and Embryonic Development. Proc. Natl. Acad. Sci., USA 98, 6842-6847. (PDF).
Zhou, H. and Thiele, D.J. 2001. Identification of a Novel High Affinity Copper Transport Complex in the Fission Yeast Schizosaccharomyes pombe. Journal of Biological Chemistry 276, 20529-20535. (PDF)
Peña, M.M.O., Puig, S. and Thiele, D.J. 2000. Functional Analysis of the Saccharomyces cerevisiae high affinity copper ion transporter Ctr3. Journal of Biological Chemistry 275, 33244-33251. (PDF)
Lee, J., Prohaska, J. R., Dagenais, S.L., Glover, T. and Thiele, D. J. 2000. Isolation of a Murine Copper Transporter Gene, Tissue Specific Expression and Functional Complementation of a Yeast Copper Transport Mutant. Gene 254, 87-96. (PDF)
Chiang, K. T., Shinyashiki, M., Switzer, C. H., Valentine, J. S., Gralla, E. B., Thiele, D. J., and Fukuto, J. M. 2000. Effects of nitric oxide on the copper-responsive transcription factor Ace1 in Saccharomyces cerevisiae: cytotoxic and cytoprotective actions of nitric oxide. Arch Biochem Biophys 377, 296-303. (PDF)
Shinyashiki, M., K.T. Chiang, C.H. Switzer, E.B. Gralla, J.S. Valentine, D.J. Thiele and Jon M. Fukuto. 2000. The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism. Proc. Natl. Acad. Sci. USA 97: 2491-2496. (PDF).
Morano, K. A., and D. J. Thiele. 1999. The Sch9 protein kinase regulates Hsp90 chaperone complex signal transduction activity in vivo. EMBO J 18:5953-5962. (PDF)
Morano, K. A., and D. J. Thiele. 1999. Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals. Gene Expr 7:271-282.
Liu, P. C., and D. J. Thiele. 1999. Modulation of human heat shock factor trimerization by the linker domain. J Biol Chem 274:17219-17225. (PDF)
Labbe, S., M. M. Pena, A. R. Fernandes, and D. J. Thiele. 1999. A copper-sensing transcription factor regulates iron uptake genes in schizosaccharomyces pombe . J Biol Chem 274:36252-36260. (PDF)
Pena, M. M., J. Lee, and D. J. Thiele. 1999. A delicate balance: homeostatic control of copper uptake and distribution. J Nutr 129:1251-1260. (PDF)
Liu, X. D., K. A. Morano, and D. J. Thiele. 1999. The yeast Hsp110 family member, Sse1, is an Hsp90 cochaperone. J Biol Chem 274:26654-26660. (PDF)
Koch, K. A., and D. J. Thiele. 1999. Functional analysis of a homopolymeric (dA-dT) element that provides nucleosomal access to yeast and mammalian transcription factors. J Biol Chem 274:23752-23760. (PDF)
Morano, K. A., N. Santoro, K. A. Koch, and D. J. Thiele. 1999. A trans-activation domain in yeast heat shock transcription factor is essential for cell cycle progression during stress. Mol Cell Biol 19:402-411. (PDF)
Labbe, S., and D. J. Thiele. 1999. Copper ion inducible and repressible promoter systems in yeast. Methods Enzymol 306:145-153.
Labbe, S., and D. J. Thiele. 1999. Pipes and wiring: the regulation of copper uptake and distribution in yeast . Trends Microbiol 7:500-505.
Zhu, Z., S. Labbe, M. M. Pena, and D. J. Thiele. 1998. Copper differentially regulates the activity and degradation of yeast Mac1 transcription factor. J Biol Chem 273:1277-1280. (PDF)
Morano, K. A., P. C. Liu, and D. J. Thiele. 1998. Protein chaperones and the heat shock response in Saccharomyces cerevisiae. Curr Opin Microbiol 1:197-203.
Santoro, N., N. Johansson, and D. J. Thiele. 1998. Heat shock element architecture is an important determinant in the temperature and transactivation domain requirements for heat shock transcription factor. Mol Cell Biol 18:6340-6352. (PDF)
Pena, M. M. O., K. A. Koch, and D. J. Thiele. 1998. Dynamic regulation of copper uptake and detoxification genes in saccharomyces cerevisiae. Mol Cell Biol 18:2514-2523. (PDF)
Liu, X. D., P. C. Liu, N. Santoro, and D. J. Thiele. 1997. Conservation of a stress response: human heat shock transcription factors functionally substitute for yeast HSF. EMBO J 16:6466-6477. (PDF)
Szczypka, M. S., Z. Zhu, P. Silar, and D. J. Thiele. 1997. Saccharomyces cerevisiae mutants altered in vacuole function are defective in copper detoxification and iron-responsive gene transcription. Yeast 13:1423-1435.
Koch, K. A., M. M. Pena, and D. J. Thiele. 1997. Copper-binding motifs in catalysis, transport, detoxification and signaling. Chem Biol 4:549-560.
Labbe, S., Z. Zhu, and D. J. Thiele. 1997. Copper-specific transcriptional repression of yeast genes encoding critical components in the copper transport pathway. J Biol Chem 272:15951-15958. (PDF)
Li, Z. S., Y. P. Lu, R. G. Zhen, M. Szczypka, D. J. Thiele, and P. A. Rea. 1997. A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium. Proc Natl Acad Sci U S A 94:42-47.
Liu, X. D., and D. J. Thiele. 1997. Yeast metallothionein gene expression in response to metals and oxidative stress. Methods 11:289-299.
Zhu, Z., and D. J. Thiele. 1996. A specialized nucleosome modulates transcription factor access to a C. glabrata metal responsive promoter. Cell 87:459-470.
Koch, K. A., and D. J. Thiele. 1996. Autoactivation by a Candida glabrata copper metalloregulatory transcription factor requires critical minor groove interactions. Mol Cell Biol 16:724-734. (PDF)
Zhu, Z., and D. J. Thiele. 1996. Toxic metal-responsive gene transcription. Exs 77:307-320.
Li, Z. S., M. Szczypka, Y. P. Lu, D. J. Thiele, and P. A. Rea. 1996. The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S- conjugate pump. J Biol Chem 271:6509-6517. (PDF)
Liu, X. D., and D. J. Thiele. 1996. Oxidative stress induced heat shock factor phosphorylation and HSF- dependent activation of yeast metallothionein gene transcription. Genes Dev 10:592-603.
Knight, S. A., S. Labbe, L. F. Kwon, D. J. Kosman, and D. J. Thiele. 1996. A widespread transposable element masks expression of a yeast copper transport gene. Genes Dev 10:1917-1929.
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