John Silberholz

John Silberholz

Assistant Professor of Technology and Operations
Ross School of Business, University of Michigan
701 Tappan Street R5468
Ann Arbor, Michigan 48109-1234

Graduate Education:
Ph.D. from MIT Operations Research Center
Undergraduate Education:
Dual B.S. degrees from University of Maryland (C.S. and Math)

Google Scholar Page

I am an Assistant Professor of Technology and Operations at the University of Michigan Ross School of Business. My current research interests lie in healthcare analytics. I am particularly interested in questions surrounding designing and learning from clinical trials, and my research relies on both analytical modeling and empirical tools to dig into this topic. I am interested not only in how to most efficiently run a clinical trial to compare a set of treatments, but also how to best select what should be compared within that clinical trial as well as how to derive as much value as possible from the results of the trial.


  Clinical Trials
(pdf) Adaptive Clinical Trial Designs with Surrogates: When Should We Bother?
Arielle Anderer, Hamsa Bastani, John Silberholz (2019)
Accepted at Management Science.
Winner of the 2019 William Pierskalla Best Paper Award.
Clinical Benefit, Toxicity and Cost of Metastatic Breast Cancer Therapies: Systematic Review and Meta-analysis
John Silberholz, Dimitris Bertsimas, Linda Vahdat (2019)
Breast Cancer Research and Treatment 176(3): 535-543..
(pdf) An Analytics Approach to Designing Combination Chemotherapy Regimens for Cancer
Dimitris Bertsimas, Allison O'Hair, Stephen Relyea, John Silberholz (2016)
Management Science 62(5): 1511-1531.
Winner of the 2013 William Pierskalla Best Paper Award.
  Other Healthcare Topics
(pdf) Can Employees' Past Helping Behavior Be Used to Improve Shift Scheduling? Evidence from ICU Nurses
Zhaohui (Zoey) Jiang, John Silberholz, Yixin (Iris) Wang, Deena Costa, Michael Sjoding (2022)
Submitted to Management Science.
(pdf) Optimal COVID-19 Containment Strategies: Evidence Across Multiple Mathematical Models
Hyun-Soo Ahn, John Silberholz, Xueze Song, Xiaoyu Wu (2022)
Preparing for resubmission.
(pdf) An Applied Informatics Decision Support Tool for Mortality Predictions in Cancer Patients
Dimitris Bertsimas, Jack Dunn, Colin Pawlowski, John Silberholz, Alexander Weinstein, Ying Daisy Zhuo, Eddy Chen, Aymen Elfiky (2018)
JCO Clinical Cancer Informatics 2, 1-11.
(pdf) Optimal healthcare decision making under multiple mathematical models: Application in prostate cancer screening
Dimitris Bertsimas, John Silberholz, Tom Trikalinos (2018)
Health Care Management Science 21(1): 105-118.
(pdf) Empirical Analysis of the Effects of Residents on Emergency Department Treatment Times
David Anderson, Bruce Golden, John Silberholz, Mike Harrington, Jon Mark Hirshon (2013)
IIE Transactions on Healthcare Systems Engineering 3(3): 171-180.
(pdf) The Impact of the Residency Teaching Model on the Efficacy of the Emergency Department at an Academic Center
John Silberholz, David Anderson, Bruce Golden, Mike Harrington, Jon Mark Hirshon (2013)
Socio-Economic Planning Sciences 47(3): 183-190.
What Works Best When? A Systematic Evaluation of Heuristics for Max-Cut and QUBO
Iain Dunning, Swati Gupta, John Silberholz (2018)
INFORMS Journal on Computing 30(3): 608-624.
Special recognition for the 2016 INFORMS Computing Society Student Paper Prize.
Comparison of Heuristics for the Colorful Traveling Salesman Problem
John Silberholz, Andrea Raiconi, Raffaele Cerulli, Monica Gentili, Bruce Golden, Si Chen (2013)
International Journal of Metaheuristics 2(2): 141-173.
Comparison of Metaheuristics
John Silberholz, Bruce Golden (2010)
Handbook of Metaheuristics (M. Gendreau and J. Potvin, eds.), Springer: 625-640.
The Effective Application of a New Approach to the Generalized Orienteering Problem
John Silberholz, Bruce Golden (2010)
Journal of Heuristics 16(3): 393-415.
Winner of the 2010 INFORMS Undergraduate Operations Research Prize.
Comparison of Heuristics for Solving the GMLST Problem
Yiwei Chen, Namrata Cornick, Andrew O. Hall, Ritvik Sahajpal, John Silberholz, Inbal Yahav, Bruce Golden (2008)
Proceedings of the 9th INFORMS Telecommunications Conference: 191-217.
The Generalized Traveling Salesman Problem: A New Genetic Algorithm Approach
John Silberholz, Bruce Golden (2007)
Proceedings of the 10th INFORMS Computing Society Conference: 165-181.
  Other topics
Measuring Utility and Speculation in Blockchain Tokens
John Silberholz, Di (Andy) Wu (2022)
Reject and resubmit at Management Science
Tenure Analytics: Models for Predicting Research Impact
Dimitris Bertsimas, Erik Brynjolfsson, Shachar Reichman, John Silberholz (2015)
Operations Research 63(6): 1246-1261.
A Course on Advanced Software Tools for Operations Research and Analytics
Iain Dunning, Vishal Gupta, Angela King, Jerry Kung, Miles Lubin, John Silberholz (2015)
INFORMS Transactions on Education 15(2): 169-179.
(pdf) Black Hole Simulations with CUDA
Frank Herrmann, John Silberholz, Manuel Tiglio (2011)
GPU Computing Gems Emerald Edition (W. Hwu, ed.), Morgan Kaufmann: 103-111.
(pdf) Statistical constraints on binary black hole inspiral dynamics
Chad Galley, Frank Herrmann, John Silberholz, Manuel Tiglio, Gustavo Guerberoff (2010)
Classical and Quantum Gravity 27(24): 245007.
Integrating Post-Newtonian Equations on Graphics Processing Units
Frank Herrmann, John Silberholz, Matias Bellone, Gustavo Guerberoff, Manuel Tiglio (2010)
Classical and Quantum Gravity 27(3): 032001.

Last modified: February 25, 2022