APPLICATIONS OF ION MOBILITY-MASS SPECTROMETRY TO DISEASE-ASSOCIATED MULTI-PROTEIN SYSTEMS
We focus much of our work on building models of unknown or partially unknown multi-protein systems involved in disease. Our general aim is to develop clear, testable models for multi-protein complexes that have refused characterization using the more-established tools of structural biology. It is our hope that the coarse-grain models we develop using the IM-MS approaches described elsewhere on this site will enable the future generation of higher-resolution structures of these complexes through the integration of IM-MS constraints with other structural data and modeling techniques. We have chosen to focus our initial model building efforts in two main areas: DNA Replication / Cancer and Amyloid Formation /Amyloid-related Diseases. Our DNA replication work is done in collaboration with groups at the University of Oxford [Robinson], California State University [Barsky], The Rockefeller University [O’Donnell], and the University of Wollongong [Dixon, Beck]. Our Amyloid work is currently performed in collaboration with groups at the University of Michigan (specifically, the Lim and Ramamoorthy groups). For a detailed summary of our current work in these areas please see our publication list.
